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  • Chapter 5: Glycolysis and Glycogenolysis
    Exercise physiology

    Chapter 5: Glycolysis and Glycogenolysis

    September 5, 2026

    Define glycolysis and describe its process Glycolysis is the first stage of cellular glucose catabolism. Skeletal muscle is…


  • Why is carbohydrate oxidation favored in short-term, hard exercise?
    Exercise physiology

    Why is carbohydrate oxidation favored in short-term, hard exercise?

    July 12, 2026

    During hard exercise, the capacity for O2 consumption can be limiting. When oxidizing carbohydrate rather than fat you…


  • The skeletal muscle lipid paradox, Type 3 diabetes and the lactate shuttle theory
    Cool lactate stuff

    The skeletal muscle lipid paradox, Type 3 diabetes and the lactate shuttle theory

    July 20, 2025

    Skeletal muscle lipid paradox – “A significant histological finding pertaining to skeletal fat metabolism occurs in physically fit…


  • Notes on: The key role of mitochondrial function in health and disease part 9
    Uncategorized

    Notes on: The key role of mitochondrial function in health and disease part 9

    July 12, 2025

    Part 9. Welcome. I learned some neat stuff from reading this paper and I would like to share:…


  • Notes on: The key role of mitochondrial function in health and disease part 8
    Uncategorized

    Notes on: The key role of mitochondrial function in health and disease part 8

    July 12, 2025

    Today I bring to you part 8 of my notes on this review paper by Inigo San-Millan. Here…


  • Notes on: The key role of mitochondrial function in health and disease part 7
    Uncategorized

    Notes on: The key role of mitochondrial function in health and disease part 7

    July 12, 2025

    Part 7. The lack of physical exercise can have deleterious effects on mitochondrial function. Physical inactivity has been…


  • Notes on: The key role of mitochondrial function in health and disease part 6
    Uncategorized

    Notes on: The key role of mitochondrial function in health and disease part 6

    July 12, 2025

    Part 6, this should be fun. Interestingly, mitochondria are the main producers of reactive oxygen species (ROS). ROS…


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Nicholas Dengler

Hello, my name is Nicholas Dengler and I am a practicing outpatient orthopedic sports physical therapist. I love to learn, teach and help others accomplish their goals.

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  • Exercise physiology
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Toxic Optimist

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